Both the Yukon and GLS have child safety locks to prevent children from opening the rear doors. The Yukon has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The GLS’ child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Yukon has a standard front seat center airbag, which deploys between the driver and front passenger, protecting them from injuries caused by striking each other in serious side impacts. The GLS doesn’t offer front seat center airbags.
A passive infrared night vision system optional on the Yukon Ultimate helps the driver to more easily detect people, animals or other objects in front of the vehicle at night. Using an infrared camera to detect heat, the system then displays the image on a monitor in the dashboard. The GLS doesn’t offer a night vision system.
The GMC Yukon’s rear backup camera has a standard washer for maintaining a clear view under various conditions. In contrast, the Mercedes GLS does not offer a rear camera washer, meaning its effectiveness relies on manual cleaning by the user when necessary.
Both the Yukon and the GLS have standard driver and passenger frontal airbags, front side-impact airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, around view monitors, rear cross-path warning, available all wheel drive and driver alert monitors.